Ontology highlight
ABSTRACT:
SUBMITTER: Sharma AK
PROVIDER: S-EPMC2629797 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Sharma Arun K AK Sharma Arati A Desai Dhimant D Madhunapantula SubbaRao V SV Huh Sung Jin SJ Robertson Gavin P GP Amin Shantu S
Journal of medicinal chemistry 20081201 24
Synthesis and identification of novel phenylalkyl isoselenocyanates (ISCs), isosteric selenium analogues of naturally occurring phenylalkyl isothiocyanates (ITCs), as effective cytotoxic and antitumor agents are described. The structure-activity relationship comparison of ISCs with ITCs and effect of the increasing alkyl chain length in inhibiting cancer cell growth were evaluated on melanoma, prostate, breast, glioblastoma, sarcoma, and colon cancer cell lines. IC(50) values for ISC compounds w ...[more]