Ontology highlight
ABSTRACT:
SUBMITTER: Markiewicz MA
PROVIDER: S-EPMC2630174 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Markiewicz Mary A MA Wise Erica L EL Buchwald Zachary S ZS Cheney Elizabeth E EE Hansen Ted H TH Suri Anish A Cemerski Saso S Allen Paul M PM Shaw Andrey S AS
Journal of immunology (Baltimore, Md. : 1950) 20090201 3
Immunological synapse formation between T cells and target cells can affect the functional outcome of TCR ligation by a given MHC-peptide complex. Although synapse formation is usually induced by TCR signaling, it is not clear whether other factors can affect the efficiency of synapse formation. Here, we tested whether cytokines could influence synapse formation between murine CTLs and target cells. We found that IL-12 enhanced synapse formation, whereas TGFbeta decreased synapse formation. The ...[more]