Ontology highlight
ABSTRACT:
SUBMITTER: Peng CC
PROVIDER: S-EPMC2630467 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Peng Chi-Chi CC Cape Jonathan L JL Rushmore Tom T Crouch Gregory J GJ Jones Jeffrey P JP
Journal of medicinal chemistry 20081201 24
CYP2C9 is a significant P450 protein responsible for drug metabolism. With the increased use of heterocyclic compounds in drug design, a rapid and efficient predrug screening of these potential type II binding compounds is essential to avoid adverse drug reactions. To understand binding modes, we use quinoline-4-carboxamide analogues to study the factors that determine the structure-activity relationships. The results of this study suggest that the more accessible pyridine with the nitrogen para ...[more]