Ontology highlight
ABSTRACT:
SUBMITTER: Chiang DY
PROVIDER: S-EPMC2630795 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Chiang Derek Y DY Getz Gad G Jaffe David B DB O'Kelly Michael J T MJ Zhao Xiaojun X Carter Scott L SL Russ Carsten C Nusbaum Chad C Meyerson Matthew M Lander Eric S ES
Nature methods 20081130 1
Cancer results from somatic alterations in key genes, including point mutations, copy-number alterations and structural rearrangements. A powerful way to discover cancer-causing genes is to identify genomic regions that show recurrent copy-number alterations (gains and losses) in tumor genomes. Recent advances in sequencing technologies suggest that massively parallel sequencing may provide a feasible alternative to DNA microarrays for detecting copy-number alterations. Here we present: (i) a st ...[more]