NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction.
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ABSTRACT:
SUBMITTER: Bradshaw NJ
PROVIDER: S-EPMC2631193 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Publications
NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction.
Bradshaw Nicholas J NJ Christie Sheila S Soares Dinesh C DC Carlyle Becky C BC Porteous David J DJ Millar J Kirsty JK
Neuroscience letters 20081106 3
Nuclear Distribution Factor E Homolog 1 (NDE1) and NDE-Like 1 (NDEL1) are highly homologous mammalian proteins. However, whereas NDEL1 is well studied, there is remarkably little known about NDE1. We demonstrate the presence of multiple isoforms of both NDE1 and NDEL1 in the brain, showing that NDE1 binds directly to multiple isoforms of Disrupted in Schizophrenia 1 (DISC1), and to itself. We also show that NDE1 can complex with NDEL1. Together these results predict a high degree of complexity o ...[more]
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