The Legionella pneumophila replication vacuole: making a cosy niche inside host cells.
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ABSTRACT:
SUBMITTER: Isberg RR
PROVIDER: S-EPMC2631402 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Publications
The Legionella pneumophila replication vacuole: making a cosy niche inside host cells.
Isberg Ralph R RR O'Connor Tamara J TJ Heidtman Matthew M
Nature reviews. Microbiology 20081117 1
The pathogenesis of Legionella pneumophila is derived from its growth within lung macrophages after aerosols are inhaled from contaminated water sources. Interest in this bacterium stems from its ability to manipulate host cell vesicular-trafficking pathways and establish a membrane-bound replication vacuole, making it a model for intravacuolar pathogens. Establishment of the replication compartment requires a specialized translocation system that transports a large cadre of protein substrates a ...[more]
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