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ABSTRACT:
SUBMITTER: Siponen M
PROVIDER: S-EPMC2632072 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Siponen Marina M Sciara Giuliano G Villion Manuela M Spinelli Silvia S Lichière Julie J Cambillau Christian C Moineau Sylvain S Campanacci Valérie V
Journal of bacteriology 20081201 3
We report here the characterization of the nonstructural protein ORF12 of the virulent lactococcal phage p2, which belongs to the Siphoviridae family. ORF12 was produced as a soluble protein, which forms large oligomers (6- to 15-mers) in solution. Using anti-ORF12 antibodies, we have confirmed that ORF12 is not found in the virion structure but is detected in the second half of the lytic cycle, indicating that it is a late-expressed protein. The structure of ORF12, solved by single anomalous di ...[more]