Ontology highlight
ABSTRACT:
SUBMITTER: Rodahl LM
PROVIDER: S-EPMC2632753 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
PloS one 20090204 2
Several regulators of endocytic trafficking have recently been identified as tumour suppressors in Drosophila. These include components of the endosomal sorting complex required for transport (ESCRT) machinery. Disruption of subunits of ESCRT-I and -II leads to cell-autonomous endosomal accumulation of ubiquitinated receptors, loss of apicobasal polarity and epithelial integrity, and increased cell death. Here we report that disruption of the ATPase dVps4, the most downstream component of the ES ...[more]