Ontology highlight
ABSTRACT:
SUBMITTER: Depaolo RW
PROVIDER: S-EPMC2633104 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Depaolo R William RW Tang Fangming F Kim Inyoung I Han Mei M Levin Nadine N Ciletti Nancy N Lin Anning A Anderson Debra D Schneewind Olaf O Jabri Bana B
Cell host & microbe 20081001 4
Educating dendritic cells (DC) to become tolerogenic DC, which promote regulatory IL-10 immune responses, represents an effective immune evasion strategy for pathogens. Yersinia pestis virulence factor LcrV is reported to induce IL-10 production via interaction with Toll-like receptor (TLR) 2. However, TLR2-/- mice are not protected against subcutaneous plague infection. Using complementary in vitro and in vivo approaches and LcrV as a model, we show that TLR6 associates with TLR2 to induce tole ...[more]