Dataset Information

Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity.

ABSTRACT:

Rationale

Privileged episodic encoding of an aversive event often comes at a cost of neutral events flanking the aversive event, resulting in decreased episodic memory for these neutral events. This peri-emotional amnesia is amygdala-dependent and varies as a function of norepinephrine activity. However, less is known about the amnesiogenic potential of cortisol.

Objective

We used a strategy of pharmacologically potentiating cortisol and norepinephrine activity to probe the putative neurochemical substrates of peri-emotional amnesia.

Materials and methods

Fifty-four healthy individuals participated in a randomized double-blind placebo-controlled study. Within the experimental context of an established peri-emotional amnesia paradigm, we tested the amnesiogenic potential of hydrocortisone (30 mg p.o.) in the presence or absence of the norepinephrine-reuptake inhibitor reboxetine (4 mg p.o.).

Results

Under dual challenge conditions, we observed a linear dose-response relationship in the magnitude and duration of emotion-induced retrograde amnesia.

Conclusions

Our results are consistent with a phenotypic expression of retrograde amnesia varying as a function of norepinephrine and cortisol coactivation during episodic encoding of aversive events. Our study demonstrates that the adverse cognitive and behavioral sequelae of aversive emotion can be experimentally modeled by a pharmacological manipulation of its putative neurochemical substrates.

SUBMITTER: Hurlemann R

PROVIDER: S-EPMC2633118 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature

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Publications

Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity.

Hurlemann René R Matusch Andreas A Hawellek Barbara B Klingmuller Dietrich D Kolsch Heike H Maier Wolfgang W Dolan Raymond J RJ

Psychopharmacology 20070624 2

<h4>Rationale</h4>Privileged episodic encoding of an aversive event often comes at a cost of neutral events flanking the aversive event, resulting in decreased episodic memory for these neutral events. This peri-emotional amnesia is amygdala-dependent and varies as a function of norepinephrine activity. However, less is known about the amnesiogenic potential of cortisol.<h4>Objective</h4>We used a strategy of pharmacologically potentiating cortisol and norepinephrine activity to probe the putati ...[more]

PMID: 17588225

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Dataset Information

Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity.

Rationale

Objective

Materials and methods

Results

Conclusions

Publications

Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity.

Similar Datasets

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