Ontology highlight
ABSTRACT:
SUBMITTER: Baker MJ
PROVIDER: S-EPMC2633397 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Baker Michael J MJ Webb Chaille T CT Stroud David A DA Palmer Catherine S CS Frazier Ann E AE Guiard Bernard B Chacinska Agnieszka A Gulbis Jacqueline M JM Ryan Michael T MT
Molecular biology of the cell 20081126 3
The Tim9-Tim10 complex plays an essential role in mitochondrial protein import by chaperoning select hydrophobic precursor proteins across the intermembrane space. How the complex interacts with precursors is not clear, although it has been proposed that Tim10 acts in substrate recognition, whereas Tim9 acts in complex stabilization. In this study, we report the structure of the yeast Tim9-Tim10 hexameric assembly determined to 2.5 A and have performed mutational analysis in yeast to evaluate th ...[more]