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Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation.


ABSTRACT: Although impaired inhibitory control is linked to a broad spectrum of health problems, including obesity, the brain mechanism(s) underlying voluntary control of hunger are not well understood. We assessed the brain circuits involved in voluntary inhibition of hunger during food stimulation in 23 fasted men and women using PET and 2-deoxy-2[(18)F]fluoro-D-glucose ((18)FDG). In men, but not in women, food stimulation with inhibition significantly decreased activation in amygdala, hippocampus, insula, orbitofrontal cortex, and striatum, which are regions involved in emotional regulation, conditioning, and motivation. The suppressed activation of the orbitofrontal cortex with inhibition in men was associated with decreases in self-reports of hunger, which corroborates the involvement of this region in processing the conscious awareness of the drive to eat. This finding suggests a mechanism by which cognitive inhibition decreases the desire for food and implicates lower ability to suppress hunger in women as a contributing factor to gender differences in obesity.

SUBMITTER: Wang GJ 

PROVIDER: S-EPMC2633545 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature

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Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation.

Wang Gene-Jack GJ   Volkow Nora D ND   Telang Frank F   Jayne Millard M   Ma Yeming Y   Pradhan Kith K   Zhu Wei W   Wong Christopher T CT   Thanos Panayotis K PK   Geliebter Allan A   Biegon Anat A   Fowler Joanna S JS  

Proceedings of the National Academy of Sciences of the United States of America 20090121 4


Although impaired inhibitory control is linked to a broad spectrum of health problems, including obesity, the brain mechanism(s) underlying voluntary control of hunger are not well understood. We assessed the brain circuits involved in voluntary inhibition of hunger during food stimulation in 23 fasted men and women using PET and 2-deoxy-2[(18)F]fluoro-D-glucose ((18)FDG). In men, but not in women, food stimulation with inhibition significantly decreased activation in amygdala, hippocampus, insu  ...[more]

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