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Chemoselective reduction of aldehydes by ruthenium trichloride and resin-bound formates.

ABSTRACT: A simple, chemoselective transfer hydrogenation of aryl aldehydes with the aid of Amberlite((R)) resin formate (ARF), a stable H-donor, in the presence of catalytic ruthenium trichloride is described. Aromatic aldehydes and 1,2-diketones are reduced efficiently and selectively, while aryl ketones remain unchanged. Several other potentially reducible groups attached to the aromatic moiety are unaffected.

SUBMITTER: Basu B

PROVIDER: S-EPMC2633666 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature

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Chemoselective reduction of aldehydes by ruthenium trichloride and resin-bound formates.

Basu Basudeb B Mandal Bablee B Das Sajal S Das Pralay P Nanda Ashis K AK

Beilstein journal of organic chemistry 20081219

A simple, chemoselective transfer hydrogenation of aryl aldehydes with the aid of Amberlite((R)) resin formate (ARF), a stable H-donor, in the presence of catalytic ruthenium trichloride is described. Aromatic aldehydes and 1,2-diketones are reduced efficiently and selectively, while aryl ketones remain unchanged. Several other potentially reducible groups attached to the aromatic moiety are unaffected. ...[more]

PMID: 19190744

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