Chemoselective reduction of aldehydes by ruthenium trichloride and resin-bound formates.

ABSTRACT: A simple, chemoselective transfer hydrogenation of aryl aldehydes with the aid of Amberlite((R)) resin formate (ARF), a stable H-donor, in the presence of catalytic ruthenium trichloride is described. Aromatic aldehydes and 1,2-diketones are reduced efficiently and selectively, while aryl ketones remain unchanged. Several other potentially reducible groups attached to the aromatic moiety are unaffected.

SUBMITTER: Basu B 

PROVIDER: S-EPMC2633666 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature