Ontology highlight
ABSTRACT:
SUBMITTER: Rooney JP
PROVIDER: S-EPMC2633870 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Rooney John P JP George Ajish D AD Patil Ashish A Begley Ulrike U Bessette Erin E Zappala Maria R MR Huang Xin X Conklin Douglas S DS Cunningham Richard P RP Begley Thomas J TJ
Genomics 20081016 1
The identification of cellular responses to damage can promote mechanistic insight into stress signalling. We have screened a library of 3968 Escherichia coli gene-deletion mutants to identify 99 gene products that modulate the toxicity of the alkylating agent methyl methanesulfonate (MMS). We have developed an ontology mapping approach to identify functional categories over-represented with MMS-toxicity modulating proteins and demonstrate that, in addition to DNA re-synthesis (replication, reco ...[more]