Ontology highlight
ABSTRACT:
SUBMITTER: de Tullio MB
PROVIDER: S-EPMC2634517 | biostudies-literature | 2008 Apr-Jun
REPOSITORIES: biostudies-literature
de Tullio Matías B MB Morelli Laura L Castaño Eduardo M EM
Prion 20080401 2
Insulin-degrading enzyme (IDE) is a conserved Zn(2+)metalloendopeptidase involved in insulin degradation and in the maintenance of brain steady-state levels of amyloid beta peptide (Abeta) of Alzheimer's disease (AD). Our recent demonstration that IDE and Abeta are capable of forming a stoichiometric and extremely stable complex raises several intriguing possibilities regarding the role of this unique protein-peptide interaction in physiological and pathological conditions. These include a prote ...[more]