Ontology highlight
ABSTRACT:
SUBMITTER: Hayashi T
PROVIDER: S-EPMC2634806 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Hayashi Tomoko T Gray Christine S CS Chan Michael M Tawatao Rommel I RI Ronacher Lisa L McGargill Maureen A MA Datta Sandip K SK Carson Dennis A DA Corr Maripat M
Proceedings of the National Academy of Sciences of the United States of America 20090202 8
Activation of Toll-like receptors (TLR) contributes to the initiation and maintenance of chronic inflammation in autoimmune diseases, yet repeated exposure to a TLR agonist can induce hyporesponsiveness to subsequent TLR stimulation. Here, we used a synthetic TLR7 agonist, 9-benzyl-8-hydroxy-2-(2-methoxyethoxy) adenine (SM360320, 1V136) to study TLR7 induced attenuation of inflammatory responses and its application to autoimmune diseases. Repeated low dose administration of this TLR7 agonist ind ...[more]