Ontology highlight
ABSTRACT:
SUBMITTER: Son GH
PROVIDER: S-EPMC2634940 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Son Gi Hoon GH Chung Sooyoung S Choe Han Kyoung HK Kim Hee-Dae HD Baik Sun-Mee SM Lee Hankyu H Lee Han-Woong HW Choi Sukwoo S Sun Woong W Kim Hyun H Cho Sehyung S Lee Kun Ho KH Kim Kyungjin K
Proceedings of the National Academy of Sciences of the United States of America 20081217 52
Glucocorticoid (GC) is an adrenal steroid with diverse physiological effects. It undergoes a robust daily oscillation, which has been thought to be driven by the master circadian clock in the suprachiasmatic nucleus of the hypothalamus via the hypothalamus-pituitary-adrenal axis. However, we show that the adrenal gland has its own clock and that the peripheral clockwork is tightly linked to steroidogenesis by the steroidogenic acute regulatory protein. Examination of mice with adrenal-specific k ...[more]