Ontology highlight
ABSTRACT:
SUBMITTER: Qiang G
PROVIDER: S-EPMC2634964 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Qiang Guan G Yang Liu L Witek Rafal P RP Jhaveri Ravi R
Virus research 20081204 1
Steatosis, or "fatty liver", is a common finding in Hepatitis C virus (HCV) infection and reflects dysregulation of lipid homeostasis. HCV Core protein causes lipid accumulation when expressed in cultured cell lines, which data now indicates is a critical step for HCV replication, assembly and release. Previous studies on HCV Core and lipid accumulation have been limited by poor efficiency of conventional transfection techniques or the cell line limitations of the available cell culture system. ...[more]