Dataset Information

Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop.

ABSTRACT: The National Heart, Lung, and Blood Institute convened an expert panel April 28 to 29, 2008, to identify gaps and recommend research strategies to prevent atrial fibrillation (AF). The panel reviewed the existing basic scientific, epidemiological, and clinical literature about AF and identified opportunities to advance AF prevention research. After discussion, the panel proposed the following recommendations: (1) enhance understanding of the epidemiology of AF in the population by systematically and longitudinally investigating symptomatic and asymptomatic AF in cohort studies; (2) improve detection of AF by evaluating the ability of existing and emerging methods and technologies to detect AF; (3) improve noninvasive modalities for identifying key components of cardiovascular remodeling that promote AF, including genetic, fibrotic, autonomic, structural, and electrical remodeling markers; (4) develop additional animal models reflective of the pathophysiology of human AF; (5) conduct secondary analyses of already-completed clinical trials to enhance knowledge of potentially effective methods to prevent AF and routinely include AF as an outcome in ongoing and future cardiovascular studies; and (6) conduct clinical studies focused on secondary prevention of AF recurrence, which would inform future primary prevention investigations.

SUBMITTER: Benjamin EJ

PROVIDER: S-EPMC2635942 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop.

Benjamin Emelia J EJ Chen Peng-Sheng PS Bild Diane E DE Mascette Alice M AM Albert Christine M CM Alonso Alvaro A Calkins Hugh H Connolly Stuart J SJ Curtis Anne B AB Darbar Dawood D Ellinor Patrick T PT Go Alan S AS Goldschlager Nora F NF Heckbert Susan R SR Jalife José J Kerr Charles R CR Levy Daniel D Lloyd-Jones Donald M DM Massie Barry M BM Nattel Stanley S Olgin Jeffrey E JE Packer Douglas L DL Po Sunny S SS Tsang Teresa S M TS Van Wagoner David R DR Waldo Albert L AL Wyse D George DG

Circulation 20090201 4

The National Heart, Lung, and Blood Institute convened an expert panel April 28 to 29, 2008, to identify gaps and recommend research strategies to prevent atrial fibrillation (AF). The panel reviewed the existing basic scientific, epidemiological, and clinical literature about AF and identified opportunities to advance AF prevention research. After discussion, the panel proposed the following recommendations: (1) enhance understanding of the epidemiology of AF in the population by systematically ...[more]

PMID: 19188521

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Project description:More than half of U.S. young adults have low ten-year but high lifetime risk of cardiovascular disease (CVD). Improving primary prevention in young adulthood may help reduce persistent CVD disparities and overall CVD morbidity and mortality. The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop in 2021 to identify potential trial opportunities in CVD prevention in young adults. The workshop identified promising interventions that could be tested, including interventions that focus on a single cardiovascular risk factor (e.g., lipids or inflammation) to multiple risk factor interventions (e.g., multicomponent lifestyle interventions or fixed-low dose combination of medications). Given the sample size and duration for a trial with hard endpoints, more research is needed on the utility of intermediate endpoints identified noninvasively such as subclinical coronary atherosclerosis as a surrogate endpoint. For now, clinical outcomes trials with hard endpoints will more likely change clinical practice. Trial efficiency depends on accurate identification of high-risk young adults, which can potentially be done using traditional risk equations, coronary artery calcium screening, computerized tomography coronary angiography, and polygenic risk scores. Trials in young adults should include enhanced recruitment strategies with intense community engagement to enroll a trial population that is racially, ethnically, geographically, and socially diverse. Despite the challenges in conducting large prevention trials in young adults, recent advances including innovation in clinical trial conduct, new therapies and successful interventions in older populations, and an increasing recognition of a lifespan approach to risk assessment have made such trials more feasible than ever.DisclosuresThe views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.

Dataset Information

Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop.

Publications

Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop.

Similar Datasets

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