Ontology highlight
ABSTRACT:
SUBMITTER: Bergo VB
PROVIDER: S-EPMC2636958 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Bergo Vladislav B VB Spudich Elena N EN Spudich John L JL Rothschild Kenneth J KJ
Biochemistry 20090201 5
We detect internal water molecules in a membrane-embedded receptor-transducer complex and demonstrate water structure changes during formation of the signaling state. Time-resolved FTIR spectroscopy reveals stimulus-induced repositioning of one or more structurally active water molecules to a significantly more hydrophobic environment in the signaling state of the sensory rhodopsin II (SRII)-transducer (HtrII) complex. These waters, distinct from bound water molecules within the SRII receptor, a ...[more]