Ontology highlight
ABSTRACT:
SUBMITTER: Inagaki M
PROVIDER: S-EPMC2637350 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Genesis (New York, N.Y. : 2000) 20080801 8
TAK1 binding protein 1 (TAB1) binds and induces autophosphorylation of TGF-beta activating kinase (TAK1). TAK1, a mitogen-activated kinase kinase kinase, is involved in several distinct signaling pathways including non-Smad pathways for TGF-beta superfamily members and inflammatory responses caused by cytokines. Conventional disruption of the murine Tab1 gene results in late gestational lethality showing intraventricular septum defects and underdeveloped lung alveoli. To gain a better understand ...[more]