Phase change material for thermotherapy of Buruli ulcer: a prospective observational single centre proof-of-principle trial.

ABSTRACT:

Background

Buruli ulcer (BU) is an infection of the subcutaneous tissue leading to chronic necrotizing skin ulcers. The causative pathogen, Mycobacterium ulcerans, grows best at 30 degrees C-33 degrees C and not above 37 degrees C. We explored the safety, tolerability and efficacy of phase change material (PCM), a novel heat application system for thermotherapy of BU.

Methodology/principal findings

In a prospective observational single centre proof-of-principle trial in Ayos/Cameroon, six laboratory reconfirmed patients with ulcerative Buruli lesions received 28-31 (ulcers < or = 2 cm) or 50-55 (ulcers > 2 cm) days of thermotherapy with the PCM sodium acetate trihydrate as heat application system. This PCM is widely used in commercial pocket heat pads, it is easy to apply, r

SUBMITTER: Junghanss T 

PROVIDER: S-EPMC2637542 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature