Ontology highlight
ABSTRACT:
SUBMITTER: Booker SJ
PROVIDER: S-EPMC2637762 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Booker Squire J SJ Cicchillo Robert M RM Grove Tyler L TL
Current opinion in chemical biology 20071001 5
The radical SAM superfamily of metalloproteins catalyze the reductive cleavage of S-adenosyl-l-methionine to generate a 5'-deoxyadenosyl radical (5'-dA*) intermediate that is obligate for turnover. The 5'-dA* acts as a potent oxidant, initiating turnover by abstracting a hydrogen atom from an appropriate substrate. A special class of these enzymes use this strategy to functionalize unactivated C-H bonds by insertion of sulfur atoms. This review will describe the characterization of three members ...[more]