Ontology highlight
ABSTRACT:
SUBMITTER: Serano J
PROVIDER: S-EPMC263820 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Serano Julia J Rubin Gerald M GM
Proceedings of the National Academy of Sciences of the United States of America 20031027 23
The vertebrate synaptotagmin-like protein granuphilin binds to the vesicle-trafficking proteins Rab27a and Munc18 and can modulate exocytosis of insulin-containing secretory granules in pancreatic beta cell lines. Here, we report the molecular and genetic characterization of bitesize, a granuphilin homolog and the only Drosophila synaptotagmin-like protein. Mutations that affect bitesize have reduced cell size and number, resulting in smaller animals that develop slowly. We also show that at lea ...[more]