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The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans.

ABSTRACT: Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)-type glutamate receptors. Using a fear conditioning and extinction paradigm in healthy normal volunteers, we show that postlearning administration of the NMDA partial agonist D-cycloserine (DCS) facilitates fear memory consolidation, evidenced behaviorally by enhanced skin conductance responses, relative to placebo, for presentations of a conditioned stimulus (CS) at a memory test performed 72 h later. DCS also enhanced CS-evoked neural responses in a posterior hippocampus/collateral sulcus region and in the medial prefrontal cortex at test. Our data suggest a role for NMDA receptors in regulating fear memory consolidation in humans.

SUBMITTER: Kalisch R

PROVIDER: S-EPMC2638747 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature

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The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans.

Kalisch Raffael R Holt Beatrice B Petrovic Predrag P De Martino Benedetto B Klöppel Stefan S Büchel Christian C Dolan Raymond J RJ

Cerebral cortex (New York, N.Y. : 1991) 20080513 1

Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)-type glutamate receptors. Using a fear conditioning and extinction paradigm in healthy normal volunteers, we show that postlearning administration of the NMDA partial agonist D-cycloserine (DCS) facilitates fear memory consolidation, evidenced behaviorally by enhanced skin conductance responses, relative to placebo, for presentations of a conditioned stimulus (CS) at a memory te ...[more]

PMID: 18477687

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