Dataset Information

Lack of replication of association between GIGYF2 variants and Parkinson disease.

ABSTRACT: Mutations in GIGYF2 have recently been described as causative of Parkinson's disease in Europeans. In an attempt to replicate these results in independent populations, we sequenced the entire coding region of GIGYF2 in a large series of Portuguese and North American samples. We report the finding of two of the previously published mutations in neurologically normal Control individuals. This suggests that mutations in GIGYF2 are not strongly related to the development of the disease in either of these populations.

SUBMITTER: Bras J

PROVIDER: S-EPMC2638775 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature

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Lack of replication of association between GIGYF2 variants and Parkinson disease.

Bras Jose J Simón-Sánchez Javier J Federoff Monica M Morgadinho Ana A Januario Cristina C Ribeiro Maria M Cunha Luis L Oliveira Catarina C Singleton Andrew B AB

Human molecular genetics 20081015 2

Mutations in GIGYF2 have recently been described as causative of Parkinson's disease in Europeans. In an attempt to replicate these results in independent populations, we sequenced the entire coding region of GIGYF2 in a large series of Portuguese and North American samples. We report the finding of two of the previously published mutations in neurologically normal Control individuals. This suggests that mutations in GIGYF2 are not strongly related to the development of the disease in either of ...[more]

PMID: 18923002

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Project description:Historically, association of disease with the major histocompatibility complex (HLA) genes has been tested with HLA alleles that encode antigen-binding affinity. The association with Parkinson disease (PD), however, was discovered with noncoding SNPs in a genome-wide association study (GWAS). We show here that several HLA-region SNPs that have since been associated with PD form two blocks tagged by rs3129882 (p = 9 × 10(-11)) and by rs9268515 and/or rs2395163 (p = 3 × 10(-11)). We investigated whether these SNP-associations were driven by HLA-alleles at adjacent loci. We imputed class I and class II HLA-alleles for 2000 PD cases and 1986 controls from the NeuroGenetics Research Consortium GWAS and sequenced a subset of 194 cases and 204 controls. We were therefore able to assess accuracy of two imputation algorithms against next-generation-sequencing while taking advantage of the larger imputed data sets for disease study. Additionally, we imputed HLA alleles for 843 cases and 856 controls from another GWAS for replication. PD risk was positively associated with the B(?)07:02_C(?)07:02_DRB5(?)01_DRB1(?)15:01_DQA1(?)01:02_DQB1(?)06:02 haplotype and negatively associated with the C(?)03:04, DRB1(?)04:04 and DQA1(?)03:01 alleles. The risk haplotype and DQA1(?)03:01 lost significance when conditioned on the SNPs, but C(?)03:04 (OR = 0.72, p = 8 × 10(-6)) and DRB1(?)04:04 (OR = 0.65, p = 4 × 10(-5)) remained significant. Similarly, rs3129882 and the closely linked rs9268515 and rs2395163 remained significant irrespective of HLA alleles. rs3129882 and rs2395163 are expression quantitative trait loci (eQTLs) for HLA-DR and HLA-DQ (9 × 10(-5) ? PeQTL ? 2 × 10(-79)), suggesting that HLA gene expression might influence PD. Our data suggest that PD is associated with both structural and regulatory elements in HLA. Furthermore, our study demonstrates that noncoding SNPs in the HLA region can be associated with disease irrespective of HLA alleles, and that observed associations with HLA alleles can sometimes be secondary to a noncoding variant.

Dataset Information

Lack of replication of association between GIGYF2 variants and Parkinson disease.

Publications

Lack of replication of association between GIGYF2 variants and Parkinson disease.

Similar Datasets

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