Ontology highlight
ABSTRACT:
SUBMITTER: Lopez LC
PROVIDER: S-EPMC2638828 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
López Luis C LC Akman Hasan O HO García-Cazorla Angeles A Dorado Beatriz B Martí Ramón R Nishino Ichizo I Tadesse Saba S Pizzorno Giuseppe G Shungu Dikoma D Bonilla Eduardo E Tanji Kurenai K Hirano Michio M
Human molecular genetics 20081121 4
Replication and repair of DNA require equilibrated pools of deoxynucleoside triphosphate precursors. This concept has been proven by in vitro studies over many years, but in vivo models are required to demonstrate its relevance to multicellular organisms and to human diseases. Accordingly, we have generated thymidine phosphorylase (TP) and uridine phosphorylase (UP) double knockout (TP(-/-)UP(-/-)) mice, which show severe TP deficiency, increased thymidine and deoxyuridine in tissues and elevate ...[more]