Ontology highlight
ABSTRACT:
SUBMITTER: Wieczorek S
PROVIDER: S-EPMC2639638 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Wieczorek Stefan S Knaup Silvia S Gross Wolfgang L WL Epplen Jörg T JT
PPAR research 20090211
A major genomic region involved in Wegener's granulomatosis includes the gene for retinoid receptor beta (RXRB) which forms heterodimers with peroxisome proliferator-activated receptors (PPARs). It is unclear whether this association directly arises from the RXRB allele(s) or via a linked variation. In order to reveal any hitherto unknown and potentially disease-relevant variation of the RXRB gene, we have genotyped four tagging SNPs of this genomic region and have directly sequenced selected WG ...[more]