Ontology highlight
ABSTRACT:
SUBMITTER: Six A
PROVIDER: S-EPMC26404 | biostudies-literature | 1996 Dec
REPOSITORIES: biostudies-literature
Six A A Rast J P JP McCormack W T WT Dunon D D Courtois D D Li Y Y Chen C H CH Cooper M D MD
Proceedings of the National Academy of Sciences of the United States of America 19961201 26
In birds and mammals T cells develop along two discrete pathways characterized by expression of either the alpha beta or the gamma delta T-cell antigen receptors (TCRs). To gain further insight into the evolutionary significance of the gamma delta T-cell lineage, the present studies sought to define the chicken TCR gamma locus. A splenic cDNA library was screened with two polymerase chain reaction products obtained from genomic DNA using primers for highly conserved regions of TCR and immunoglob ...[more]