Evolution of proviral gp120 over the first year of HIV-1 subtype C infection.
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ABSTRACT:
SUBMITTER: Novitsky V
PROVIDER: S-EPMC2642736 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Publications
Evolution of proviral gp120 over the first year of HIV-1 subtype C infection.
Novitsky Vladimir V Lagakos Stephen S Herzig Michaela M Bonney Caitlin C Kebaabetswe Lemme L Rossenkhan Raabya R Nkwe David D Margolin Lauren L Musonda Rosemary R Moyo Sikhulile S Woldegabriel Elias E van Widenfelt Erik E Makhema Joseph J Essex M M
Virology 20081029 1
The evolution of proviral gp120 during the first year after seroconversion in HIV-1 subtype C infection was addressed in a case series of eight subjects. Multiple viral variants were found in two out of eight cases. Slow rate of viral RNA decline and high early viral RNA set point were associated with a higher level of proviral diversity from 0 to 200 days after seroconversion. Proviral divergence from MRCA over the same period also differed between subjects with slow and fast decline of viral R ...[more]
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