Ontology highlight
ABSTRACT:
SUBMITTER: Owens P
PROVIDER: S-EPMC2642977 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Owens Philip P Bazzi Hisham H Engelking Erin E Han Gangwen G Christiano Angela M AM Wang Xiao-Jing XJ
Developmental biology 20080726 1
We have previously shown that keratinocyte-specific deletion of Smad4, a TGFbeta/Activin/BMP signaling mediator, results in a progressive alopecia. To further assess the molecular mechanisms of Smad4 loss-mediated alopecia, we examined expression levels of key molecules associated with hair follicle differentiation in Smad4-deleted skin. Among them, Desmoglein 4 (Dsg4) was down-regulated in Smad4-deleted skin prior to the onset of hair follicle abnormalities with gradual depletion coinciding wit ...[more]