A stress signaling pathway in adipose tissue regulates hepatic insulin resistance.
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ABSTRACT:
SUBMITTER: Sabio G
PROVIDER: S-EPMC2643026 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance.
Sabio Guadalupe G Das Madhumita M Mora Alfonso A Zhang Zhiyou Z Jun John Y JY Ko Hwi Jin HJ Barrett Tamera T Kim Jason K JK Davis Roger J RJ
Science (New York, N.Y.) 20081201 5907
A high-fat diet causes activation of the regulatory protein c-Jun NH2-terminal kinase 1 (JNK1) and triggers development of insulin resistance. JNK1 is therefore a potential target for therapeutic treatment of metabolic syndrome. We explored the mechanism of JNK1 signaling by engineering mice in which the Jnk1 gene was ablated selectively in adipose tissue. JNK1 deficiency in adipose tissue suppressed high-fat diet-induced insulin resistance in the liver. JNK1-dependent secretion of the inflammat ...[more]
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