Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC2643075 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Wang Ling L Tang Yong Y Cole Philip A PA Marmorstein Ronen R
Current opinion in structural biology 20081027 6
The recent structure and associated biochemical studies of the metazoan-specific p300/CBP and fungal-specific Rtt109 histone acetyltransferases (HATs) have provided new insights into the ancestral relationship between HATs and their functions. These studies point to a common HAT ancester that has evolved around a common structural framework to form HATs with divergent catalytic and substrate-binding properties. These studies also point to the importance of regulatory loops within HATs and autoac ...[more]