Ontology highlight
ABSTRACT:
SUBMITTER: Merrick KA
PROVIDER: S-EPMC2643088 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Molecular cell 20081201 5
In metazoans, different cyclin-dependent kinases (CDKs) bind preferred cyclin partners to coordinate cell division. Here, we investigate these preferences in human cells and show that cyclin A assembles with Cdk1 only after complex formation with Cdk2 reaches a plateau during late S and G2 phases. To understand the basis for Cdk2's competitive advantage, despite Cdk1's greater abundance, we dissect their activation pathways by chemical genetics. Cdk1 and Cdk2 are activated by kinetically distinc ...[more]