Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection.
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ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC2643775 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection.
Liu Shufeng S Yang Wei W Shen Le L Turner Jerrold R JR Coyne Carolyn B CB Wang Tianyi T
Journal of virology 20081203 4
A tight junction (TJ) protein, claudin-1 (CLDN1), was identified recently as a key factor for hepatitis C virus (HCV) entry. Here, we show that another TJ protein, occludin, is also required for HCV entry. Mutational study of CLDN1 revealed that its tight junctional distribution plays an important role in mediating viral entry. Together, these data support the model in which HCV enters liver cells from the TJ. Interestingly, HCV infection of Huh-7 hepatoma cells downregulated the expression of C ...[more]
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