Ontology highlight
ABSTRACT:
SUBMITTER: Beutler BA
PROVIDER: S-EPMC2644070 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
One of the most fundamental questions in immunology pertains to the recognition of non-self, which for the most part means microbes. How do we initially realize that we have been inoculated with microbes, and how is the immune response ignited? Genetic studies have made important inroads into this question during the past decade, and we now know that in mammals, a relatively small number of receptors operate to detect signature molecules that herald infection. One or more of these signature mole ...[more]