Ontology highlight
ABSTRACT:
SUBMITTER: Agosta F
PROVIDER: S-EPMC2644156 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Agosta Federica F Vossel Keith A KA Miller Bruce L BL Migliaccio Raffaella R Bonasera Stephen J SJ Filippi Massimo M Boxer Adam L AL Karydas Anna A Possin Katherine L KL Gorno-Tempini Maria Luisa ML
Proceedings of the National Academy of Sciences of the United States of America 20090122 6
Apolipoprotein epsilon4 (apoE4) has been strongly linked with Alzheimer's disease (AD) and contributes to several other neurological disorders. We investigated the influence of epsilon4 allele carrier status on the pattern of gray matter atrophy and disease severity in 51 patients with probable AD and 31 patients with behavioral variant frontotemporal dementia (bvFTD), compared with 56 healthy controls. Voxel-based morphometry was performed by using statistical parametric mapping. The epsilon4 a ...[more]