Ontology highlight
ABSTRACT:
SUBMITTER: Billon-Gales A
PROVIDER: S-EPMC2644162 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Billon-Galés Audrey A Fontaine Coralie C Filipe Cédric C Douin-Echinard Victorine V Fouque Marie-José MJ Flouriot Gilles G Gourdy Pierre P Lenfant Françoise F Laurell Henrik H Krust Andrée A Chambon Pierre P Arnal Jean-François JF
Proceedings of the National Academy of Sciences of the United States of America 20090202 6
Full-length 66-kDa estrogen receptor alpha (ERalpha) stimulates target gene transcription through two activation functions (AFs), AF-1 in the N-terminal domain and AF-2 in the ligand binding domain. Another physiologically expressed 46-kDa ERalpha isoform lacks the N-terminal A/B domains and is consequently devoid of AF-1. Previous studies in cultured endothelial cells showed that the N-terminal A/B domain might not be required for estradiol (E2)-elicited NO production. To evaluate the involveme ...[more]