Ontology highlight
ABSTRACT:
SUBMITTER: Gordus A
PROVIDER: S-EPMC2644171 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Gordus Andrew A Krall Jordan A JA Beyer Elsa M EM Kaushansky Alexis A Wolf-Yadlin Alejandro A Sevecka Mark M Chang Bryan H BH Rush John J MacBeath Gavin G
Molecular systems biology 20090120
Receptor tyrosine kinases (RTKs) process extracellular cues by activating a broad array of signaling proteins. Paradoxically, they often use the same proteins to elicit diverse and even opposing phenotypic responses. Binary, 'on-off' wiring diagrams are therefore inadequate to explain their differences. Here, we show that when six diverse RTKs are placed in the same cellular background, they activate many of the same proteins, but to different quantitative degrees. Additionally, we find that the ...[more]