Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation.

ABSTRACT: Ambient particulate matter is increasingly recognized as a significant contributor to human cardiopulmonary morbidity and mortality in the United States and worldwide. We sought to determine whether exposure to ambient particulate matter would alter alveolar fluid clearance in mice. Mice were exposed to a range of doses of a well-characterized particulate matter collected from the ambient air in Düsseldorf, Germany through a single intratracheal instillation, and alveolar fluid clearance and measurements of lung injury were made. Exposure to even very low doses of particulate matter (10 microg) resulted in a significant reduction in alveolar fluid clearance that was maximal 24 h after the exposure, with complete resolution after 7 d. This was paralleled by a decrease in lung Na,K-ATPase ac

SUBMITTER: Mutlu GM 

PROVIDER: S-EPMC2644228 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature