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Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness.

ABSTRACT: Asthma is a ubiquitous disease with a broad range of clinical phenotypes. To better understand the complex genetic and environmental interactions underlying asthma, we compared the gene-gene interactions of four genetically distinct mouse strains that demonstrate biologically distinct responses to allergen. Using DNA microarrays and knock-out mouse studies, we showed that CCR5 plays a definitive role in the development of ovalbumin-induced allergic airway inflammatory disease. In addition, gene expression profiling data have revealed other potential novel targets for therapeutics-based research and has enhanced the understanding of the molecular mechanisms underlying the etiology of "asthma."

SUBMITTER: Walker JK

PROVIDER: S-EPMC2644233 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature

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Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness.

Walker Julia K L JK Ahumada Adriana A Frank Bryan B Gaspard Renee R Berman Katherine K Quackenbush John J Schwartz David A DA

American journal of respiratory cell and molecular biology 20060210 6

Asthma is a ubiquitous disease with a broad range of clinical phenotypes. To better understand the complex genetic and environmental interactions underlying asthma, we compared the gene-gene interactions of four genetically distinct mouse strains that demonstrate biologically distinct responses to allergen. Using DNA microarrays and knock-out mouse studies, we showed that CCR5 plays a definitive role in the development of ovalbumin-induced allergic airway inflammatory disease. In addition, gene ...[more]

PMID: 16474097

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