A genome screen for quantitative trait loci influencing schizophrenia and neurocognitive phenotypes.

ABSTRACT:

Objective

Deficits in neurocognitive function have been demonstrated in individuals with schizophrenia and in the unaffected family members of these individuals. Genetic studies of such complementary traits, along with traditional analyses of diagnosis, may help to elucidate the biological pathways underlying familial liability to schizophrenia and related disorders. The authors conducted a multiplex, multigenerational family study using a genome-wide screen for schizophrenia and related neurocognitive phenotypes.

Method

Participants were 1) 676 European American individuals from 43 families, ascertained through an individual with schizophrenia, and 2) 236 healthy comparison subjects. Participants were evaluated clinically and examined through the use of a computerized neuro

SUBMITTER: Almasy L 

PROVIDER: S-EPMC2644284 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature