Unknown

Dataset Information

0

Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder.


ABSTRACT:

Background

Attention deficit hyperactivity disorder (ADHD) is a complex neurobehavioral disorder. The dopamine transporter gene (DAT1/SLC6A3) has been considered a good candidate for ADHD. Most association studies with ADHD have investigated the 40-base-pair variable number of tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1. Only few studies have reported association between promoter polymorphisms of the gene and ADHD.

Methods

To investigate the association between the polymorphisms -67A/T (rs2975226) and -839C/T (rs2652511) in promoter region of DAT1 in ADHD, two samples of ADHD patients from the UK (n = 197) and Taiwan (n = 212) were genotyped, and analysed using within-family transmission disequilibrium test (TDT).

Results

A significant association was found between the T allele of promoter polymorphism -67A/T and ADHD in the Taiwanese population (P = 0.001). There was also evidence of preferential transmission of the T allele of -67A/T polymorphism in combined samples from the UK and Taiwan (P = 0.003). No association was detected between the -839C/T polymorphism and ADHD in either of the two populations.

Conclusion

The finding suggests that genetic variation in the promoter region of DAT1 may be a risk factor in the development of ADHD.

SUBMITTER: Xu X 

PROVIDER: S-EPMC2644291 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder.

Xu Xiaohui X   Mill Jonathan J   Sun Bo B   Chen Chih-Ken CK   Huang Yu-Shu YS   Wu Yu-Yu YY   Asherson Philip P  

BMC psychiatry 20090205


<h4>Background</h4>Attention deficit hyperactivity disorder (ADHD) is a complex neurobehavioral disorder. The dopamine transporter gene (DAT1/SLC6A3) has been considered a good candidate for ADHD. Most association studies with ADHD have investigated the 40-base-pair variable number of tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1. Only few studies have reported association between promoter polymorphisms of the gene and ADHD.<h4>Methods</h4>To investigate the association  ...[more]

Similar Datasets

| S-EPMC4823197 | biostudies-literature
| S-EPMC4641275 | biostudies-literature
| S-EPMC4093913 | biostudies-literature
| S-EPMC3164006 | biostudies-literature
| S-EPMC4225213 | biostudies-literature
| S-EPMC5639140 | biostudies-literature
| S-EPMC1748193 | biostudies-literature
| S-EPMC6456487 | biostudies-literature
| S-EPMC4377310 | biostudies-literature
| S-EPMC7880081 | biostudies-literature