Ontology highlight
ABSTRACT:
SUBMITTER: Marlow LA
PROVIDER: S-EPMC2644344 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Marlow Laura A LA Reynolds Lisa A LA Cleland Alan S AS Cooper Simon J SJ Gumz Michelle L ML Kurakata Shinichi S Fujiwara Kosaku K Zhang Ying Y Sebo Thomas T Grant Clive C McIver Bryan B Wadsworth J Trad JT Radisky Derek C DC Smallridge Robert C RC Copland John A JA
Cancer research 20090210 4
Anaplastic thyroid carcinoma (ATC) is a highly aggressive form of the disease for which new therapeutic options are desperately needed. Previously, we showed that the high-affinity peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, RS5444, inhibits cell proliferation of ATC cells via induction of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) (p21). We show here that up-regulation of RhoB is a critical step in PPARgamma-mediated activation of p21-induced cell stasis. Usi ...[more]