Ontology highlight
ABSTRACT:
SUBMITTER: Shibutani ST
PROVIDER: S-EPMC2644461 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Shibutani Shusaku T ST de la Cruz Aida Flor A AF Tran Vuong V Turbyfill William J WJ Reis Tânia T Edgar Bruce A BA Duronio Robert J RJ
Developmental cell 20081201 6
E2F transcription factors are key regulators of cell proliferation that are inhibited by pRb family tumor suppressors. pRb-independent modes of E2F inhibition have also been described, but their contribution to animal development and tumor suppression is unclear. Here, we show that S phase-specific destruction of Drosophila E2f1 provides a novel mechanism for cell cycle regulation. E2f1 destruction is mediated by a PCNA-interacting-protein (PIP) motif in E2f1 and the Cul4(Cdt2) E3 ubiquitin liga ...[more]