Ontology highlight
ABSTRACT:
SUBMITTER: Panasenko OO
PROVIDER: S-EPMC2644939 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Panasenko Olesya O OO David Fabrice P A FP Collart Martine A MA
Genetics 20081215 2
In this work we addressed the role of ubiquitination in the function of the nascent polypeptide-associated complex (NAC), named EGD in the yeast Saccharomyces cerevisiae. To this end, we first identified the lysines residues required for ubiquitination of EGD/NAC. While simultaneous mutation of many lysines in the alpha-subunit of NAC (Egd2p) was required to abolish its ubiquitination, for the beta-subunit of NAC (Egd1p), mutation of K29 and K30 was sufficient. We determined that the ubiquitinat ...[more]