Ontology highlight
ABSTRACT:
SUBMITTER: Hampel H
PROVIDER: S-EPMC2645108 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Hampel Heather H Frankel Wendy L WL Martin Edward E Arnold Mark M Khanduja Karamjit K Kuebler Philip P Clendenning Mark M Sotamaa Kaisa K Prior Thomas T Westman Judith A JA Panescu Jenny J Fix Dan D Lockman Janet J LaJeunesse Jennifer J Comeras Ilene I de la Chapelle Albert A
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080922 35
<h4>Purpose</h4>Identifying individuals with Lynch syndrome (LS) is highly beneficial. However, it is unclear whether microsatellite instability (MSI) or immunohistochemistry (IHC) should be used as the screening test and whether screening should target all patients with colorectal cancer (CRC) or those in high-risk subgroups.<h4>Patients and methods</h4>MSI testing and IHC for the four mismatch repair proteins was performed on 500 tumors from unselected patients with CRC. If either MSI or IHC w ...[more]