Heterogeneous sensory innervation and extensive intrabulbar connections of olfactory necklace glomeruli.

ABSTRACT: The mammalian nose employs several olfactory subsystems to recognize and transduce diverse chemosensory stimuli. These subsystems differ in their anatomical position within the nasal cavity, their targets in the olfactory forebrain, and the transduction mechanisms they employ. Here we report that they can also differ in the strategies they use for stimulus coding. Necklace glomeruli are the sole main olfactory bulb (MOB) targets of an olfactory sensory neuron (OSN) subpopulation distinguished by its expression of the receptor guanylyl cyclase GC-D and the phosphodiesterase PDE2, and by its chemosensitivity to the natriuretic peptides uroguanylin and guanylin and the gas CO(2). In stark contrast to the homogeneous sensory innervation of canonical MOB glomeruli from OSNs expressing the same

SUBMITTER: Cockerham RE 

PROVIDER: S-EPMC2645502 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature