Ontology highlight
ABSTRACT:
SUBMITTER: Perkovic M
PROVIDER: S-EPMC2645832 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Perkovic Mario M Schmidt Stanislaw S Marino Daniela D Russell Rebecca A RA Stauch Benjamin B Hofmann Henning H Kopietz Ferdinand F Kloke Björn-Philipp BP Zielonka Jörg J Ströver Heike H Hermle Johannes J Lindemann Dirk D Pathak Vinay K VK Schneider Gisbert G Löchelt Martin M Cichutek Klaus K Münk Carsten C
The Journal of biological chemistry 20081212 9
The APOBEC3 cytidine deaminases are part of the intrinsic defense of cells against retroviruses. Lentiviruses and spumaviruses have evolved essential accessory proteins, Vif and Bet, respectively, which counteract the APOBEC3 proteins. We show here that Bet of the Prototype foamy virus inhibits the antiviral APOBEC3C activity by a mechanism distinct to Vif: Bet forms a complex with APOBEC3C without inducing its degradation. Bet abolished APOBEC3C dimerization as shown by coimmunoprecipitation an ...[more]