Oxo-ester mediated native chemical ligation: concept and applications.
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ABSTRACT:
SUBMITTER: Wan Q
PROVIDER: S-EPMC2645925 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Oxo-ester mediated native chemical ligation: concept and applications.
Wan Qian Q Chen Jin J Yuan Yu Y Danishefsky Samuel J SJ
Journal of the American Chemical Society 20081101 47
A direct oxo-ester peptide ligation method has been developed. Through the use of an activated C-terminal para nitrophenyl ester (1), it is possible to achieve direct cysteine ligations (1 + 2 --> 4). Peptide substrates incorporating bulky C-terminal amino acids (1) can be accommodated with high reaction efficiency. ...[more]
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