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Oxo-ester mediated native chemical ligation: concept and applications.


ABSTRACT: A direct oxo-ester peptide ligation method has been developed. Through the use of an activated C-terminal para nitrophenyl ester (1), it is possible to achieve direct cysteine ligations (1 + 2 --> 4). Peptide substrates incorporating bulky C-terminal amino acids (1) can be accommodated with high reaction efficiency.

SUBMITTER: Wan Q 

PROVIDER: S-EPMC2645925 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Oxo-ester mediated native chemical ligation: concept and applications.

Wan Qian Q   Chen Jin J   Yuan Yu Y   Danishefsky Samuel J SJ  

Journal of the American Chemical Society 20081101 47


A direct oxo-ester peptide ligation method has been developed. Through the use of an activated C-terminal para nitrophenyl ester (1), it is possible to achieve direct cysteine ligations (1 + 2 --> 4). Peptide substrates incorporating bulky C-terminal amino acids (1) can be accommodated with high reaction efficiency. ...[more]

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